Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice.

Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice.

Similar to pancreatic islets, submandibular glands are more rapidly infiltrated in female NOD mice than in males. The present comparative analysis of cellular infiltrations in lacrimal glands, however, revealed the opposite finding. At 12 wk of age, approximately 25% of male lacrimal tissue area is infiltrated, whereas age-matched female NOD mice still lack major signs of inflammation. T cells ...

Breaking self-tolerance in nonobese diabetic mice

Unresponsiveness to self is maintained through two mechanisms of immune regulation: thymic-negative selection and peripheral tolerance. Although thymic-negative selection is a major mechanism to eliminate self-reactive T cells, normal mice have readily detectable populations of T cells reactive to self-proteins but do not exhibit autoimmune responses. It has been postulated that autoimmune dise...

Nonobese Diabetic Mice in T Cells and Diabetes Protection in TLR9 Deficiency Promotes CD73 Expression

Neonatal Tumor Necrosis Factor a Promotes Diabetes in Nonobese Diabetic Mice by CD154-independent Antigen

Neonatal islet-specific expression of tumor necrosis factor (TNF)a in nonobese diabetic mice promotes diabetes by provoking islet-infiltrating antigen-presenting cells to present islet peptides to autoreactive T cells. Here we show that TNFa promotes autoaggression of both effector CD4 1 and CD8 1 T cells. Whereas CD8 1 T cells are critical for diabetes progression, CD4 1 T cells play a lesser ...

Diabetic Mice Diabetes Development in Young Nonobese Systemic Administration of IL-18 Promotes